Stay on the right side of disruption

Disruption is rippling through the global economy at a rapid pace. Such dramatic change is being felt across industries and geographies, and potentially shaping the long-term performance of investors’ portfolios. At Janus Henderson, we use fundamental analysis in an effort to identify new investment opportunities and stay on the right side of disruption.

Three major trends behind disruption

We believe three megatrends are helping transform the global economy and creating new investment opportunities:

A Technological Revolution

Cloud computing, mobility, the Internet of Things and artificial intelligence are some of the powerful and investable trends reshaping the global economy.

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A New Era for Health Care

A growing understanding of the human genome and robust computing power are helping transform the health care sector unlike ever before.

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Sustainable Investing

Investing in businesses that are strategically aligned with the powerful environmental and social trends changing the shape of the global economy.

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Harness the power of disruption in your portfolio

A time of accelerating change can be unsettling for investors and make it harder to achieve financial goals. Janus Henderson’s expert investment teams can help offer solutions.

  • Janus Henderson Horizon Global Technology Fund invests in a globally diversified portfolio of technology-related companies.

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  • Janus Henderson Horizon Global Sustainable Equity Fund invests at least 80% of its NAV in equities of companies worldwide, whose products and services are considered as contributing to positive environmental or social change.
  • Janus Henderson Horizon Biotechnology Fund invests at least 80% of its NAV in equities and equity-related instruments of biotechnology and biotechnology-related companies worldwide.
  • Investments involve varying degree of investment risks (e.g. liquidity, market, economic, political, regulatory, taxation, financial, interest rate, hedging and currency risks). In extreme market conditions, you may lose your entire investment.
  • Investments in financial derivatives instruments (“FDIs”) (such as futures, swaps, options, forward rate notes, and forward foreign exchange contracts) involve specific risks (e.g. counterparty, liquidity, leverage, volatility, valuation, short position and over-the-counter transaction risk).
  • Some sub-funds may use FDIs for investment purposes (up to 10% of its net assets) and / or for hedging and/or efficient portfolio management purposes.
  • Some sub-funds may invest in certain geographical area(s) /industry sector (e.g. technology, property) and may subject them to higher concentration risk.
  • Some sub-funds may invest in Eurozone (in particular Portugal, Italy, Ireland, Greece and Spain) securities and may suffer from Eurozone sovereign debt crisis risk.
  • Some sub-funds may be subject to various risks relating to sustainable investment approach, including concentration risk, subjective judgment in investment selection, exclusion risk, risk of reliance on corporate data or third-party information and change in nature of investments.
  • Janus Henderson Balanced Fund; Janus Henderson Global Life Sciences Fund; Janus Henderson US Forty Fund
  • Some sub-funds may invest in any one or a combination of the following instruments:
    • futures, options and swaps and other FDI for investment purposes, up to 10% of the net asset value ("NAV") of the sub-fund. Given the leverage effect of FDI, such investments may result in substantial loss (as much as 100% of the NAV of the relevant sub-fund);
    • debt securities rated below investment grade;
    • fixed and floating rate investment grade bonds; and
    • mortgage and asset-backed securities and/or in index/structured securities. These financial instruments may be rated below investment grade.
  • Investing in any one of the above instruments may involve substantial credit/counterparty, market, liquidity, currency, leverage, index, interest, swap and downgrading risks. If the issuers default, or such securities or their underlying assets, cannot be realised or perform badly, investors’ entire investments may be lost.
  • Some sub-funds' A inc share class may at its discretion (i) pay dividends out of the capital of the sub-fund, and (ii) pay dividends out of gross income while charging all or part of the fees and expenses to the capital of the sub-fund, resulting in an increase in distributable income available for the payment of dividends by the sub-fund and therefore, the sub-fund may effectively pay dividends out of capital. This may result in an immediate reduction of the sub-fund’s net asset value per share, and it amounts to a return or withdrawal of part of an investor’s original investment or from any capital gains attributable to that original investment.
  • Some sub-funds' investments involve developing markets. Owing to its potentially higher volatility and risk levels, as well as lower political and economic stability than developed markets, asset values could be affected in various levels.
  • Some sub-fund’s investments may be more concentrated in terms of industry risk than others that diversify across industries and may therefore be subject to higher industry risk than sub-funds with more diversified holdings.
  • Some sub-fund’s investments may be more concentrated than others that diversify across investments and may therefore be subject to higher risk than sub-funds with more diversified investments.

The investment decision is yours. If you are in any doubt about the contents of this document, you should seek independent professional financial advice. Investors should not only base on this document alone to make investment decisions and should read the offering documents including the risk factors for further details.


Balanced Fund

For over 20 years, this dynamic allocation strategy has delivered our equity and fixed income expertise in a one-stop core solution.
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Global Life Sciences Fund

By understanding the science and business of health care, the strategy invests in companies addressing unmet medical needs or improving health care efficiencies.
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Horizon Biotechnology Fund

Investing in innovative companies addressing high unmet medical needs or improving the standard of care in the fast growing biotechnology sector.
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Horizon Global Technology Leaders Fund

A portfolio that balances resilience with optionality, investing in growth companies driving or benefiting from advances in technology.
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Horizon Global Sustainable Equity Fund

A global equity strategy employing an integrated approach to sustainable and responsible investment.
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US Forty Fund

Our differentiated view from the market identifies growth where growth is scarce, which we believe positions our investments to outperform the index over time.
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From 1 July 2020, the fund name changed from Janus Henderson Horizon Global Technology Fund to Janus Henderson Horizon Global Technology Leaders Fund.

An investment approach driven by bold thinking

We believe in confronting uncertainty head-on – not merely reacting to change but finding opportunity in it. Hear from our investment professionals on how they apply this approach in their fundamental research, part of an ethos we call
Knowledge. Shared.

Investing sustainably through the COVID crisis

Hamish Chamberlayne, Head of Global Sustainable Equities, explains how the global sustainable equity investing has fared through the COVID crisis so far and discusses how they have navigated the recent market rotation from growth to value factors.

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What will it take to reopen the global economy?

An update on vaccines, fatality rates and lessons learned as economies reopen – the latest in a video series on the scientific and investment implications of COVID-19.

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Technology for good: supporting the fight against COVID-19

Alison Porter, Graeme Clark and Richard Clode from the Global Technology Team discuss how ‘big tech’ companies are helping communities and governments through the pandemic and the implications this may have on the regulation of the technology sector.

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