Mid-Year Market GPS: Disruptive Forces

Which themes are shaping the 2019 investment landscape? Read our investment teams’ thinking in the Janus Henderson Mid-Year Market GPS.

Portfolio Managers Andy Acker and Denny Fish explore disruptive forces in health care and technology.

Disruption is being felt across industries and geographies and proving to be a differentiator in the long-term performance of investors’ portfolios. Such rapid and widespread change is creating new investment opportunities but also significant risks. For the first half of 2019, these trends continued, particularly in the technology and health care sectors.

Technology: The Long Game

The technology sector is writing the operating system for a digital global economy. But as the first half of 2019 showed, the sector itself is an evolving playing field, which can increase the breadth of potential outcomes. Internet platforms, for one, have faced greater calls for regulation and potential antitrust investigations, trends that could persist for the near term. Meanwhile, semiconductors have been caught up in escalating trade disputes and tech wars, whipping around these stocks.

We cannot forecast the outcome of trade spats or how tight the regulatory noose might be pulled. But the shift to a digital economy is continuing, and the opportunities created by this transition – especially in cloud computing, the Internet of Things, artificial intelligence and 5G – is likely to be a significant source of earnings growth over the long term. Consequently, we believe investors should keep business cycles in perspective, even as regulatory and supply-chain details are hammered out over the near term.

Semiconductors: Volatility Hits Stocks, but EPS Growth Is Expected to Continue

Semiconductors: Volatility Hits Stocks, but EPS Growth Is Expected to Continue | Janus Henderson

Source: Bloomberg, data as of 5/10/19

Health Care: Medical Advances and M&A

Proposals for drug pricing reform and a single-payer medical system in the U.S. weighed on health care stocks in the first half of 2019. But these headwinds have not gotten in the way of innovation. On the contrary, advances in genetic sequencing, new modalities for targeting disease and accommodative regulatory paths are helping fuel medical breakthroughs – many of which are being spearheaded by small and midsize companies. Consequently, we have seen a surge in mergers and acquisitions (M&A), often at significant premiums.

Innovation looks set to continue. In the coming months, we expect results from landmark studies for cancer-fighting immunotherapies, while new technology is emerging in medtech, such as robotic-assisted surgeries. And in May, the Food and Drug Administration approved the second gene therapy in the U.S., a treatment for spinal muscular atrophy, the leading genetic cause of infant death. In our view, these and other advances could lead to significant growth for the companies developing the products, as well as fuel additional M&A.

A Surge in M&A

Year to date, the value of announced biotechnology and pharmaceutical deals already equals 55% or more of total M&A in each of the last five years.

A Surge in M&A | Janus Henderson

Source: Bloomberg. YTD as of 5/6/19

Investment Themes that Matter – Market GPS Discussion

Janus Henderson experts Alex Crooke (equities), Michael Ho (multi asset/alternatives) and Jim Cielinski (fixed income) explore the key themes for the second half of 2019. Aligning with the Janus Henderson Mid-Year Market GPS outlooks, the discussion will assess potential impacts and opportunities for investors in the months ahead.
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Concentrated investments in a single sector, industry or region will be more susceptible to factors affecting that group and may be more volatile than less concentrated investments or the market as a whole.