For investors in Singapore

Horizon Biotechnology Fund

A fund investing in innovative companies addressing high unmet medical needs or improving the standard of care in the fast-growing biotechnology sector.


USD 19.41
As of 2023/09/25

1-Day Change
USD -0.06 (-0.31%)
As of 2023/09/25

Morningstar Rating

As of 2023/08/31



The Biotechnology Fund aims to provide capital growth.

The Fund invests at least 80% of its net assets in equities and equity-related instruments of biotechnology and biotechnology-related companies worldwide. “Biotechnology and biotechnology-related companies” is defined as:


• companies that are included in the NASDAQ Biotechnology Index;
• companies that develop small molecule or biologic drugs subject to the approval of global regulatory agencies;
• companies that market products or services to aid in the research and development of small molecule or biologic drugs; or
• companies that are considered such by the Investment Manager.

In choosing investments, the Investment Manager aims to select biotechnology companies that he or she believes to be undervalued, with greater potential for clinical and/or commercial success than is currently reflected in market prices.

The Fund may invest in companies of any size, including smaller capitalisation companies.

Equity-related instruments may include depository receipts and derivative instruments (such as futures, forwards, equity swaps (also known as contract-for-differences), swaps and options and warrants).

The Fund may use derivative instruments for investment purposes (up to 10% of its net assets) and hedging purposes. The underlyings consist of a range of securities or indices that the Fund may invest in according to the Fund’s investment objective and policy,

The Investment Manager may from time to time consider hedging currency and interest rates exposure, but will not generally enter into contracts involving a speculative position in any currency or interest rate.

On an ancillary basis and for defensive purposes, the Fund may invest in:
• convertible bonds and associated derivative instruments;
• cash, money market instruments or derivative instruments that are used to provide downside market protection or dampen market volatility.


Note: You should not make investment decisions based solely on marketing materials. You should read the Prospectus and the Product Highlights Sheet of the Fund for more details of the investment risks and seek independent professional advice where appropriate.


Experienced and Specialised Investment Team: Dedicated biotechnology specialists with deep scientific backgrounds and a distinguished record of investing in biotechnology stocks. This highly specialised team is supported by the larger Janus Henderson health care team with over a century of combined health care investing experience.

Differentiated Fundamental Research: Seek to understand the science and the business to identify opportunities and mitigate the clinical and commercial risks inherent in the sector.

Disciplined Investment Process: Balanced across development stage, early commercial and profitable biotechnology companies and augmented by a differentiated Value at Risk Framework designed to mitigate the volatility associated with drug development.


Top holdings can be found in the factsheet of the fund.


Andy Acker, CFA

Portfolio Manager

Industry since 1996. Joined Firm in 1999.

Daniel Lyons, Ph.D., CFA

Portfolio Manager | Research Analyst

Industry since 2000. Joined Firm in 2000.

Agustin Mohedas, Ph.D.

Portfolio Manager | Research Analyst

Industry since 2014.


Discrete Performance (%)
As of 2023/06/30
A2 USD (Net)
Quarter End
As of 2023/06/30
Jun-2022 - Jun-2023 Jun-2021 - Jun-2022 Jun-2020 - Jun-2021 Jun-2019 - Jun-2020 Jun-2018 - Jun-2019
A2 USD (Net) 50.67 -32.16 34.42 35.29 -
Cumulative & Annualised Performance (%)
As of 2023/08/31
A2 USD (Net) NASDAQ Biotechnology Total Return
  Cumulative Annualised
1MO 3MO 6MO YTD 1YR 3YR 5YR 10YR Since Inception
A2 USD (Net) 0.10 2.64 13.73 12.43 37.10 10.35 - - 16.56
NASDAQ Biotechnology Total Return -0.24 1.23 1.41 -1.79 7.42 -0.41 - - 5.73
Calendar Year Returns (%)
As of 2023/06/30
A2 USD (Net) NASDAQ Biotechnology Total Return
2022 2021 2020 2019
A2 USD (Net) -3.78 -5.17 61.32 34.70
NASDAQ Biotechnology Total Return -10.12 0.02 26.42 25.11
Initial Charge 5.00%
Annual Charge 1.20%
Ongoing Charge
(As of 2022/06/30)
Performance Fee 20% of the 'Relevant Amount'
Hurdle Rate NASDAQ Biotechnology Total Return Index