For Individual Investors in the US

Global Life Sciences Fund Holdings

Full Portfolio Holdings

(As of August 31, 2023)

% OF INVESTMENTS
UnitedHealth Group Inc 6.11
Eli Lilly & Co 4.78
AstraZeneca PLC 3.94
Novo Nordisk A/S 3.60
Sanofi 2.95
Merck & Co Inc 2.85
Abbott Laboratories 2.64
AbbVie Inc 2.48
Sarepta Therapeutics Inc 2.43
Thermo Fisher Scientific Inc 2.43
Boston Scientific Corp 2.32
Vertex Pharmaceuticals Inc 2.31
Novartis AG (ADR) 2.25
Danaher Corp 2.24
Roche Holding AG 1.85
Argenx SE (ADR) 1.77
Stryker Corp 1.64
Elevance Health Inc 1.58
Cencora Inc 1.27
Humana Inc 1.26
HCA Healthcare Inc 1.25
ImmunoGen Inc 1.22
Vaxcyte Inc 1.20
Ascendis Pharma A/S (ADR) 1.20
Akero Therapeutics Inc 1.18
Amgen Inc 1.13
Zoetis Inc 1.13
Madrigal Pharmaceuticals Inc 1.10
BioMarin Pharmaceutical Inc 1.07
Illumina Inc 1.02
Neurocrine Biosciences Inc 1.01
Edwards Lifesciences Corp 1.00
Intuitive Surgical Inc 0.98
Cooper Cos Inc 0.94
United Therapeutics Corp 0.93
Medtronic PLC 0.93
PTC Therapeutics Inc 0.92
Centene Corp 0.90
Astellas Pharma Inc 0.90
Globus Medical Inc 0.85
Johnson & Johnson 0.84
Avadel Pharmaceuticals PLC (ADR) 0.81
STERIS PLC 0.80
Bayer AG 0.79
DexCom Inc 0.79
Pfizer Inc 0.77
Legend Biotech Corp (ADR) 0.73
Zai Lab Ltd (ADR) 0.72
Amicus Therapeutics Inc 0.70
Baxter International Inc 0.66
Cytokinetics Inc 0.61
Penumbra Inc 0.60
Teleflex Inc 0.59
Royalty Pharma plc 0.58
Catalent Inc 0.56
Align Technology Inc 0.56
Biohaven Ltd 0.53
REVOLUTION Medicines Inc 0.53
Gilead Sciences Inc 0.51
Regeneron Pharmaceuticals Inc 0.51
IQVIA Holdings Inc 0.50
Cymabay Therapeutics Inc 0.48
Prothena Corp PLC 0.48
Travere Therapeutics Inc 0.47
Alnylam Pharmaceuticals Inc 0.47
Takeda Pharmaceutical Co Ltd 0.46
Organon & Co 0.45
DENTSPLY SIRONA Inc 0.45
Ardelyx Inc 0.43
Ventyx Biosciences Inc 0.41
NeoGenomics Inc 0.39
Tandem Diabetes Care Inc 0.39
Arcellx Inc 0.37
89bio Inc 0.34
Moderna Inc 0.33
ICON PLC 0.33
New Horizon Health Ltd 0.32
4D Molecular Therapeutics Inc 0.31
Roivant Sciences Ltd 0.30
Biomea Fusion Inc 0.30
Rhythm Pharmaceuticals Inc 0.27
Insmed Inc 0.27
Lantheus Holdings Inc 0.26
Ideaya Biosciences Inc 0.26
ACELYRIN Inc 0.25
Replimune Group Inc 0.21
ICU Medical Inc 0.20
Collegium Pharmaceutical Inc 0.20
Mirum Pharmaceuticals Inc 0.20
Privia Health Group Inc 0.20
Intra-Cellular Therapies Inc 0.18
Bicycle Therapeutics PLC (ADR) 0.18
Element Biosciences Inc 0.15
Bigfoot Biomedical Inc 0.14
Disc Medicine Inc/old 0.13
Janux Therapeutics Inc 0.13
Shoreline Biosciences Inc 0.13
Synthekine Inc 0.12
Heartflow Inc 0.12
Seres Therapeutics Inc 0.11
Curevo Inc 0.11
Freenome Holdings Inc 0.08
Freenome Holdings Inc 0.08
Lexeo Therapeutics Inc 0.08
Sonoma Biotherapeutics Inc 0.08
Attralus Inc 0.07
Magnolia Medical Technologies Inc 0.07
Arbor Biotechnologies Inc 0.05
Neurogene Inc 0.05
Neurogene Inc 0.05
Hemoshear Therapeutics LLC 0.04
Sonoma Biotherapeutics Inc 0.04
Asher Biotherapeutics Inc 0.04
Twinstrand Biosciences Inc 0.03
Bigfoot Biomedical Inc 0.02
Lexeo Therapeutics Inc 0.02
Leap Therapeutics Inc 0.02
ACELYRIN INC 0.02
Canbridge Pharmaceuticals Inc 0.01
Leap Therapeutics Inc 0.00
Leap Therapeutics Inc 0.00
Clementia Pharmaceuticals Inc 0.00
SomaLogic Operating Co Inc 0.00
Cash & Equivalents 0.60
Janus Henderson publishes this listing of securities held as of the most recently available disclosure period, which varies depending on the portfolio. Any portion of holdings may be excluded from publication when deemed in the best interest of the portfolio. Securities are reported at market value.
The portfolio data and its presentation here is based on the investment book of record and may differ from the accounting book of record and complete schedules of investments in regulatory filings due to differing accounting and reporting standards.