Please ensure Javascript is enabled for purposes of website accessibility Global Life Sciences Fund - Janus Henderson Investors
For Financial Professionals in the US

JFNIX Global Life Sciences Fund

The fund/portfolio seeks to harness the rapid innovation in health care to generate returns by investing in companies addressing unmet medical needs or those that seek to make the health care system more efficient.

NAV
$70.69
As of 04/15/2024

1-Day Change
-$0.50 (-0.70%)
 As of 04/15/2024

YTD Return
2.05%
As of 04/15/2024

Morningstar Rating

As of 03/31/2024

Overview

ABOUT THIS FUND

The fund seeks to harness the rapid innovation in health care to generate returns by investing in companies addressing unmet medical needs or those that seek to make the health care system more efficient.

WHY INVEST IN THIS FUND

Health Care Expertise: Our domain experts have 95+ years of combined experience investing in the complex and dynamic health care sector. Our team of specialists, which include multiple Ph.D.’s, seek to understand both the science and the business of prospective investments.

Balanced Approach: We diversify the portfolio across market capitalizations, geographies and the primary sub-sectors of health care, including investments in biotechnology, health care services, medical devices and pharmaceuticals.

Integrated Risk Management Process: Security-level “Value at Risk” framework focuses attention on downside risks by limiting the position size of higher-risk stocks.

PORTFOLIO MANAGEMENT

Andy Acker, CFA

Andy Acker, CFA

Portfolio Manager

Industry since 1996. Joined Firm in 1999.

Daniel Lyons, Ph.D., CFA

Daniel Lyons, Ph.D., CFA

Portfolio Manager | Research Analyst

Industry since 2000. Joined Firm in 2000.

Performance

RETURNS (%) (As of 03/31/2024)
Global Life Sciences Fund - I Shares MSCI World Health Care IndexSM S&P 500® Index
 
3M YTD 1YR 3YR 5YR 10YR Since Inception
(12/31/1998)
Global Life Sciences Fund - I Shares 8.56 8.56 18.25 7.65 11.61 11.70 11.59
MSCI World Health Care IndexSM 7.47 7.47 13.32 7.85 10.33 9.18 6.96
S&P 500® Index 10.56 10.56 29.88 11.49 15.04 12.96 7.91
Returns quoted are past performance and do not guarantee future results; current performance may be lower or higher. Investment returns and principal value will vary; there may be a gain or loss when shares are sold.
Performance for Class I Shares that includes periods prior to 7/6/09 reflects the performance of one or more share classes of the Fund or a predecessor fund, adjusted, where applicable and permitted, for differing fees and expenses. See the Fund’s prospectus for further details.

Returns include reinvestment of dividends and capital gains. Returns greater than one year are annualized.

RETURNS (%) (As of 03/31/2024)
Global Life Sciences Fund - I Shares MSCI World Health Care IndexSM S&P 500® Index
 
3M YTD 1YR 3YR 5YR 10YR Since Inception
(12/31/1998)
Global Life Sciences Fund - I Shares 8.56 8.56 18.25 7.65 11.61 11.70 11.59
MSCI World Health Care IndexSM 7.47 7.47 13.32 7.85 10.33 9.18 6.96
S&P 500® Index 10.56 10.56 29.88 11.49 15.04 12.96 7.91
Returns quoted are past performance and do not guarantee future results; current performance may be lower or higher. Investment returns and principal value will vary; there may be a gain or loss when shares are sold.
Performance for Class I Shares that includes periods prior to 7/6/09 reflects the performance of one or more share classes of the Fund or a predecessor fund, adjusted, where applicable and permitted, for differing fees and expenses. See the Fund’s prospectus for further details.

Returns include reinvestment of dividends and capital gains. Returns greater than one year are annualized.

Calendar Year Returns (%)
Global Life Sciences Fund - I Shares MSCI World Health Care IndexSM
2023 2022 2021 2020 2019 2018 2017 2016 2015 2014
Global Life Sciences Fund - I Shares 7.54 -2.65 6.86 25.60 29.28 4.41 22.66 -12.27 8.42 34.93
MSCI World Health Care IndexSM 3.76 -5.41 19.80 13.52 23.24 2.51 19.80 -6.81 6.60 18.10

MORNINGSTAR PERCENTILE

(As Of 03/31/2024)
1 YR 3 YR 5 YR 10 YR SINCE INCEPTION
Percentile Ranking 18 12 9 8 7
Health | Rank/Count 39/177 22/159 18/138 11/127 4/57
(As Of 03/31/2024)
1 YR 3 YR 5 YR 10 YR SINCE INCEPTION
Percentile Ranking 18 12 9 8 7
Health | Rank / Count 39/177 22/159 18/138 11/127 4/57

GROWTH OF A HYPOTHETICAL INVESTMENT

Global Life Sciences Fund - I Shares MSCI World Health Care IndexSM Health
Source: Morningstar, Inc.
This graph compares the performance of a hypothetical $1 investment in the fund, the fund’s Morningstar category average and its benchmark(s).

RETURNS-BASED STATISTICS (As of 03/31/2024 Class I Shares)

RISK / REWARD
VS. MSCI World Health Care NR Index		 3YR 5YR
Information Ratio -0.03 0.18
Alpha -0.02 1.19
Tracking Error 5.63 6.42
Beta 1.00 1.03
R-squared (%) 86.78 84.50
UP/DOWN MARKET CAPTURE (%)
VS. MSCI World Health Care NR Index		 3YR 5YR
Up Capture Ratio 97.16 103.24
Down Capture Ratio 98.17 97.59
STANDARD DEVIATION 3YR 5YR
Global Life Sciences Fund 15.29 16.24
MSCI World Health Care NR Index 14.17 14.53
SHARPE RATIO 3YR 5YR
Global Life Sciences Fund 0.31 0.58
MSCI World Health Care NR Index 0.35 0.56
ANNUAL FEES & EXPENSES (As of the most recent prospectus)
CLASS I SHARES
Management Fees 0.64%
Other Expenses 0.13%
Total Gross Expenses 0.77%
Total Net Expenses 0.77%

Portfolio

Index represents the MSCI World Health Care Index.

Top Holdings (As of 03/31/2024)
% of Fund
Eli Lilly & Co 7.08
UnitedHealth Group Inc 5.86
Novo Nordisk A/S 5.19
Merck & Co Inc 3.64
AstraZeneca PLC 3.58
AbbVie Inc 3.36
Sanofi SA 2.49
Boston Scientific Corp 2.31
Vertex Pharmaceuticals Inc 2.30
Abbott Laboratories 2.27
TOTAL 38.08
View full holdings
Portfolio Characteristics (As of 03/31/2024)
  FUND INDEX
Number of Holdings
Equity Issues		 120 136
Market Capitalization
Weighted Average		 $176.46B $214.93B
Portfolio Turnover Rate
(1-year trailing)		 34.26% -
Price/Earnings Ratio
(1-year forward)		 20.28 18.67
Price/Book Ratio
 5.20 4.47
Earnings Growth Rate
(1-year forward)		 22.94% 18.91%
Sector Allocation % OF FUND % of Index % OF FUND % of Index (As of 03/31/2024)
Regional Allocation % OF FUND % of Index % OF FUND % of Index (As of 03/31/2024)
Market Capitalization Range of Equity Holdings % OF FUND % of Index % OF FUND % of Index (As of 03/31/2024)
Developed vs Emerging Markets % OF FUND % of Index % OF FUND % of Index (As of 03/31/2024)

Documents

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