Please ensure Javascript is enabled for purposes of website accessibility Global Life Sciences Fund - Janus Henderson Investors - US Advisor
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For Financial Professionals in the US

JFNIX Global Life Sciences Fund

The fund/portfolio seeks to harness the rapid innovation in health care to generate returns by investing in companies addressing unmet medical needs or those that seek to make the health care system more efficient.

NAV
$66.28
As of 07/03/2025

1-Day Change
$0.05 (0.08%)
 As of 07/03/2025

YTD Return
-2.56%
As of 07/03/2025

Morningstar Rating

As of 06/30/2025

Morningstar Medalist Rating ™

Bronze Morningstar Analyst Rating
As of 10/07/2024

Overview

ABOUT THIS FUND

The fund seeks to harness the rapid innovation in health care to generate returns by investing in companies addressing unmet medical needs or those that seek to make the health care system more efficient.

WHY INVEST IN THIS FUND

Health Care Expertise: Our domain experts have 95+ years of combined experience investing in the complex and dynamic health care sector. Our team of specialists, which include multiple Ph.D.’s, seek to understand both the science and the business of prospective investments.

Balanced Approach: We diversify the portfolio across market capitalizations, geographies and the primary sub-sectors of health care, including investments in biotechnology, health care services, medical devices and pharmaceuticals.

Integrated Risk Management Process: Security-level “Value at Risk” framework focuses attention on downside risks by limiting the position size of higher-risk stocks.

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Insight-led approach helping clients invest in a brighter future.

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Portfolio Management

Andy Acker, CFA: Portfolio Manager
Andy Acker, CFA

Portfolio Manager

Industry since 1996. Joined Firm in 1999.

Daniel Lyons, Ph.D., CFA: Portfolio Manager | Research Analyst
Daniel Lyons, Ph.D., CFA

Portfolio Manager | Research Analyst

Industry since 2000. Joined Firm in 2000.

Performance

RETURNS (%) (As of 03/31/2025)
Global Life Sciences Fund - I Shares MSCI World Health Care IndexSM S&P 500® Index
 
3M YTD 1YR 3YR 5YR 10YR Since Inception
(12/31/1998)
Global Life Sciences Fund - I Shares 0.99 0.99 -3.61 4.95 11.24 7.42 10.97
MSCI World Health Care IndexSM 5.10 5.10 -1.10 2.58 9.89 7.01 6.64
S&P 500® Index -4.27 -4.27 8.25 9.06 18.59 12.50 7.92
Returns quoted are past performance and do not guarantee future results; current performance may be lower or higher. Investment returns and principal value will vary; there may be a gain or loss when shares are sold.

Returns include reinvestment of dividends and capital gains. Returns greater than one year are annualized.

Mutual fund performance for some periods may incorporate returns from older share classes, adjusted for fees and expenses. Visit janushenderson.com/synthetic for specific details.
RETURNS (%) (As of 05/31/2025)
Global Life Sciences Fund - I Shares MSCI World Health Care IndexSM S&P 500® Index
 
3M YTD 1YR 3YR 5YR 10YR Since Inception
(12/31/1998)
Global Life Sciences Fund - I Shares -10.15 -5.03 -8.21 5.54 6.23 6.26 10.64
MSCI World Health Care IndexSM -7.65 -0.64 -5.19 2.11 5.47 6.13 6.37
S&P 500® Index -0.37 1.06 13.52 14.41 15.95 12.86 8.09
Returns quoted are past performance and do not guarantee future results; current performance may be lower or higher. Investment returns and principal value will vary; there may be a gain or loss when shares are sold.

Returns include reinvestment of dividends and capital gains. Returns greater than one year are annualized.

Mutual fund performance for some periods may incorporate returns from older share classes, adjusted for fees and expenses. Visit janushenderson.com/synthetic for specific details.
Calendar Year Returns (%)
Global Life Sciences Fund - I Shares MSCI World Health Care IndexSM
2024 2023 2022 2021 2020 2019 2018 2017 2016 2015
Global Life Sciences Fund - I Shares 3.63 7.54 -2.65 6.86 25.60 29.28 4.41 22.66 -12.27 8.42
MSCI World Health Care IndexSM 1.13 3.76 -5.41 19.80 13.52 23.24 2.51 19.80 -6.81 6.60
Returns quoted are past performance and do not guarantee future results; current performance may be lower or higher. Investment returns and principal value will vary; there may be a gain or loss when shares are sold.

Returns include reinvestment of dividends and capital gains. Returns greater than one year are annualized.

Mutual fund performance for some periods may incorporate returns from older share classes, adjusted for fees and expenses. Visit janushenderson.com/synthetic for specific details.

Morningstar Percentile

 (As of 06/30/2025)
1 YR 3 YR 5 YR 10 YR SINCE INCEPTION
Percentile Ranking 75 15 21 20 8
US Fund Health | Rank/Count 125/176 28/164 26/150 23/128 5/55
 (As of 06/30/2025)
1 YR 3 YR 5 YR 10 YR SINCE INCEPTION
Percentile Ranking 75 15 21 20 8
US Fund Health | Rank / Count 125/176 28/164 26/150 23/128 5/55

Growth of a Hypothetical Investment

Global Life Sciences Fund - I Shares MSCI World Health Care IndexSM S&P 500® Index Health
Source: Morningstar, Inc.

This graph compares the performance of a hypothetical $1 investment in the fund, the fund’s Morningstar category average and its benchmark(s). Fund performance is on a Net Asset Value (NAV) basis with net income reinvested where applicable.

Returns-Based Statistics (As of 04/30/2025 Class I Shares)

RISK / REWARD
VS. MSCI World Health Care NR Index		 3YR 5YR
Information Ratio 0.78 0.23
Alpha 3.65 1.61
Tracking Error 4.66 5.99
Beta 0.99 0.98
R-squared (%) 89.45 83.83
UP/DOWN MARKET CAPTURE (%)
MSCI World Health Care NR Index		 3YR 5YR
Up Capture Ratio 107.76 95.90
Down Capture Ratio 90.08 89.66
STANDARD DEVIATION 3YR 5YR
Global Life Sciences Fund 14.10 14.78
MSCI World Health Care NR Index 13.44 13.80
SHARPE RATIO 3YR 5YR
Global Life Sciences Fund 0.19 0.38
MSCI World Health Care NR Index -0.07 0.31
Annual Fees & Expenses (As of the most recent prospectus)
CLASS I SHARES
Management Fees 0.64%
Other Expenses 0.13%
Total Gross Expenses 0.77%
Total Net Expenses 0.77%

Portfolio

Index represents the MSCI World Health Care Index.

Top Holdings (As of 05/31/2025)
% of Fund
Eli Lilly & Co 8.64
UnitedHealth Group Inc 4.47
AstraZeneca PLC 4.41
Boston Scientific Corp 3.46
Abbott Laboratories 3.40
Johnson & Johnson 3.27
Sanofi SA 3.04
Amgen Inc 2.82
Novartis AG (ADR) 2.62
Argenx SE (ADR) 2.59
TOTAL 38.72
View full holdings
Portfolio Characteristics (As of 05/31/2025)
  FUND INDEX
Number of Holdings
Equity Issues		 104 130
Market Capitalization
Weighted Average		 $159.30B $185.93B
Portfolio Turnover Rate
(1-year trailing)		 32.52% -
Price/Earnings Ratio
(1-year forward)		 17.90 15.78
Price/Book Ratio
 4.33 3.90
Earnings Growth Rate
(1-year forward)		 19.44% 16.20%
Industry Breakdown % of Fund % of Index % of Fund % of Index As of 05/31/2025
Regional Allocation % of Fund % of Index % of Fund % of Index As of 05/31/2025
Developed vs Emerging Markets % of Fund % of Index % of Fund % of Index As of 05/31/2025
Market Capitalization Range of Equity Holdings % of Fund % of Index % of Fund % of Index As of 05/31/2025

Documents

Related Insights

Our intellectual capital is readily available and central to our Knowledge Shared approach"
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