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For Individual Investors in the US

Global Life Sciences Fund Holdings

Full Portfolio Holdings

(As of March 31, 2026)

% OF INVESTMENTS
Eli Lilly & Co 8.89
Johnson & Johnson 7.31
AstraZeneca PLC 4.60
AbbVie Inc 4.08
UnitedHealth Group Inc 3.14
Novartis AG (ADR) 2.85
Thermo Fisher Scientific Inc 2.51
Praxis Precision Medicines Inc 2.45
Argenx SE (ADR) 2.40
Abbott Laboratories 2.40
Roche Holding AG 2.22
Bridgebio Pharma Inc 2.21
Sanofi SA 2.08
Intuitive Surgical Inc 2.04
REVOLUTION Medicines Inc 2.04
Vertex Pharmaceuticals Inc 1.98
HCA Healthcare Inc 1.88
Boston Scientific Corp 1.84
Amgen Inc 1.83
Ascendis Pharma A/S (ADR) 1.65
Stryker Corp 1.65
Danaher Corp 1.64
CVS Health Corp 1.48
Madrigal Pharmaceuticals Inc 1.48
Merck & Co Inc 1.48
PTC Therapeutics Inc 1.35
United Therapeutics Corp 1.33
McKesson Corp 1.33
Gilead Sciences Inc 1.31
Globus Medical Inc 1.24
Mirum Pharmaceuticals Inc 1.22
Teva Pharmaceutical Industries Ltd (ADR) 1.18
Vaxcyte Inc 1.09
Medtronic PLC 0.97
Elevance Health Inc 0.93
Dyne Therapeutics Inc 0.88
Cencora Inc 0.84
Travere Therapeutics Inc 0.82
Lantheus Holdings Inc 0.76
Medline Inc 0.74
Edwards Lifesciences Corp 0.72
DexCom Inc 0.68
Soleno Therapeutics Inc 0.64
Apogee Therapeutics Inc 0.62
UCB SA 0.61
Becton Dickinson & Co 0.55
Glaukos Corp 0.55
Structure Therapeutics Inc (ADR) 0.53
Ideaya Biosciences Inc 0.47
Tarsus Pharmaceuticals Inc 0.40
Edgewise Therapeutics Inc 0.40
Penumbra Inc 0.40
Xenon Pharmaceuticals Inc 0.39
Cooper Cos Inc 0.39
Cogent Biosciences Inc 0.37
Biohaven Ltd 0.36
Regeneron Pharmaceuticals Inc 0.36
Daiichi Sankyo Co Ltd 0.36
STERIS PLC 0.35
Neurocrine Biosciences Inc 0.35
Protagonist Therapeutics Inc 0.33
Scholar Rock Holding Corp 0.32
Zoetis Inc 0.30
Ardelyx Inc 0.30
Alnylam Pharmaceuticals Inc 0.29
Sotera Health Co 0.29
Crinetics Pharmaceuticals Inc 0.28
Heartflow Inc 0.27
Rhythm Pharmaceuticals Inc 0.27
Nuvalent Inc 0.25
Illumina Inc 0.24
Insulet Corp 0.24
KARDIUM SERIES 8 CLASS D PREFERRED SHARES USD 0.24
Teleflex Inc 0.23
Mirum Pharmaceuticals Inc 0.22
Centene Corp 0.22
Janux Therapeutics Inc 0.19
Olema Pharmaceuticals Inc 0.19
Terns Pharmaceuticals Inc 0.19
Humana Inc 0.18
4D Molecular Therapeutics Inc 0.15
Immunome Inc 0.15
Curevo Inc 0.10
Lexeo Therapeutics Inc 0.07
Loadsmart Inc 0.07
Magnolia Medical Technologies Inc 0.05
Element Biosciences Inc 0.05
Green Cross Holdings Corp 0.04
PFIZER INC 0.04
Twinstrand Biosciences Inc 0.03
Freenome Holdings Inc 0.02
Freenome Holdings Inc 0.02
Sonoma Biotherapeutics Inc 0.02
Asher Biotherapeutics Inc 0.02
Sonoma Biotherapeutics Inc 0.01
Attralus Inc 0.01
Asher Biotherapeutics Inc 0.01
Novo Nordisk A/S 0.01
Hemoshear Therapeutics LLC 0.01
Alkermes PLC 0.01
Cash & Equivalents 0.45
Janus Henderson publishes this listing of securities held as of the most recently available disclosure period, which varies depending on the portfolio. Any portion of holdings may be excluded from publication when deemed in the best interest of the portfolio. Securities are reported at market value.
The portfolio data and its presentation here is based on the investment book of record and may differ from the accounting book of record and complete schedules of investments in regulatory filings due to differing accounting and reporting standards.