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Global Life Sciences Diversified ADR Managed Account Holdings

Full Portfolio Holdings

(As of 11/30/2025)

% OF INVESTMENTS
Eli Lilly & Co 9.83
Johnson & Johnson 5.38
AstraZeneca PLC (ADR) 4.36
UnitedHealth Group Inc 3.40
AbbVie Inc 3.36
Argenx SE (ADR) 2.99
Abbott Laboratories 2.72
Boston Scientific Corp 2.43
Sanofi SA (ADR) 2.39
Thermo Fisher Scientific Inc 2.35
Amgen Inc 2.35
Novartis AG (ADR) 2.29
Intuitive Surgical Inc 2.28
HCA Healthcare Inc 2.14
Vertex Pharmaceuticals Inc 2.03
Bridgebio Pharma Inc 1.97
REVOLUTION Medicines Inc 1.89
Danaher Corp 1.81
Praxis Precision Medicines Inc 1.79
Stryker Corp 1.74
Roche Holding AG (ADR) 1.72
Avidity Biosciences Inc 1.58
CVS Health Corp 1.56
Madrigal Pharmaceuticals Inc 1.54
Ascendis Pharma A/S (ADR) 1.49
McKesson Corp 1.44
Globus Medical Inc 1.30
PTC Therapeutics Inc 1.29
Medtronic PLC 1.26
Gilead Sciences Inc 1.18
Dyne Therapeutics Inc 1.16
Cencora Inc 1.12
Travere Therapeutics Inc 1.04
Teva Pharmaceutical Industries Ltd (ADR) 1.03
Soleno Therapeutics Inc 0.99
Vaxcyte Inc 0.93
Mirum Pharmaceuticals Inc 0.92
United Therapeutics Corp 0.91
Elevance Health Inc 0.87
Daiichi Sankyo Co Ltd (ADR) 0.79
Edwards Lifesciences Corp 0.75
Akero Therapeutics Inc 0.67
Lantheus Holdings Inc 0.61
Becton Dickinson & Co 0.59
Regeneron Pharmaceuticals Inc 0.55
Ideaya Biosciences Inc 0.53
Apogee Therapeutics Inc 0.52
DexCom Inc 0.51
Glaukos Corp 0.50
Nuvalent Inc 0.49
Penumbra Inc 0.48
Janux Therapeutics Inc 0.45
Insmed Inc 0.44
STERIS PLC 0.44
Alnylam Pharmaceuticals Inc 0.42
Cooper Cos Inc 0.42
Tarsus Pharmaceuticals Inc 0.41
Neurocrine Biosciences Inc 0.39
Zoetis Inc 0.36
Sotera Health Co 0.36
Inspire Medical Systems Inc 0.35
Edgewise Therapeutics Inc 0.34
Ardelyx Inc 0.32
Avadel Pharmaceuticals PLC 0.31
Arcellx Inc 0.31
Structure Therapeutics Inc (ADR) 0.30
Crinetics Pharmaceuticals Inc 0.30
Scholar Rock Holding Corp 0.27
Centene Corp 0.27
Xenon Pharmaceuticals Inc 0.26
Illumina Inc 0.25
Align Technology Inc 0.24
Teleflex Inc 0.24
Amicus Therapeutics Inc 0.23
Humana Inc 0.23
Cogent Biosciences Inc 0.23
Legend Biotech Corp (ADR) 0.22
Protagonist Therapeutics Inc 0.21
Biohaven Ltd 0.16
PFIZER INC 0.04
Cash & Equivalents 1.41
Janus Henderson publishes this listing of securities held as of the most recently available disclosure period, which varies depending on the portfolio. Any portion of holdings may be excluded from publication when deemed in the best interest of the portfolio. Securities are reported at market value.