For Financial Professionals in the US

Global Life Sciences Fund Holdings

Full Portfolio Holdings

(As of 06/30/2022)

% OF INVESTMENTS
UnitedHealth Group Inc 6.51
AstraZeneca PLC 4.75
AbbVie Inc 4.01
Eli Lilly & Co 3.06
Bristol-Myers Squibb Co 2.73
Merck & Co Inc 2.73
Thermo Fisher Scientific Inc 2.62
Roche Holding AG 2.60
Abbott Laboratories 2.51
Vertex Pharmaceuticals Inc 2.41
Sanofi 2.41
Novartis AG (ADR) 2.29
Danaher Corp 2.18
Boston Scientific Corp 2.17
Sarepta Therapeutics Inc 2.11
Humana Inc 2.06
Elevance Health Inc 2.03
Centene Corp 1.91
Novo Nordisk A/S 1.66
Argenx SE (ADR) 1.57
Neurocrine Biosciences Inc 1.55
Jazz Pharmaceuticals PLC 1.37
Edwards Lifesciences Corp 1.35
BioMarin Pharmaceutical Inc 1.32
Pfizer Inc 1.31
Horizon Therapeutics Plc 1.28
Johnson & Johnson 1.19
Teleflex Inc 1.17
Ascendis Pharma A/S (ADR) 1.17
AmerisourceBergen Corp 1.14
Organon & Co 1.14
Astellas Pharma Inc 1.10
Align Technology Inc 1.01
Royalty Pharma plc 0.95
Illumina Inc 0.90
United Therapeutics Corp 0.90
Stryker Corp 0.90
IQVIA Holdings Inc 0.87
Amicus Therapeutics Inc 0.87
Cooper Cos Inc 0.86
Medtronic PLC 0.84
STERIS PLC 0.83
Global Blood Therapeutics Inc 0.79
Insmed Inc 0.78
Gilead Sciences Inc 0.78
Regeneron Pharmaceuticals Inc 0.72
DexCom Inc 0.70
Intuitive Surgical Inc 0.69
Globus Medical Inc 0.66
Takeda Pharmaceutical Co Ltd 0.65
DENTSPLY SIRONA Inc 0.64
Elanco Animal Health Inc 0.61
PTC Therapeutics Inc 0.59
Travere Therapeutics Inc 0.58
IVERIC bio Inc 0.58
Zai Lab Ltd (ADR) 0.57
Catalent Inc 0.56
Insulet Corp 0.50
Harmony Biosciences Holdings Inc 0.49
Alnylam Pharmaceuticals Inc 0.49
ICON PLC 0.48
Myovant Sciences Ltd 0.43
Penumbra Inc 0.43
Bayer AG 0.38
Quest Diagnostics Inc 0.37
ICU Medical Inc 0.36
Privia Health Group Inc 0.32
Collegium Pharmaceutical Inc 0.32
Moderna Inc 0.28
Silk Road Medical Inc 0.25
Bigfoot Biomedical Inc 0.24
Vaxcyte Inc 0.22
Akero Therapeutics Inc 0.22
Mirati Therapeutics Inc 0.20
Sage Therapeutics Inc 0.20
Biohaven Pharmaceutical Holding Co Ltd 0.19
Sotera Health Co 0.19
Bicycle Therapeutics PLC (ADR) 0.19
Biomea Fusion Inc 0.19
Janux Therapeutics Inc 0.18
Element Biosciences Inc 0.17
Tandem Diabetes Care Inc 0.16
Nuvalent Inc 0.16
Synthekine Inc 0.15
Lexeo Therapeutics Inc 0.15
ValenzaBio Inc 0.15
Shoreline Biosciences Inc 0.15
Health Catalyst Inc 0.14
Ventyx Biosciences Inc 0.14
LifeStance Health Group Inc 0.14
Design Therapeutics Inc 0.13
Fate Therapeutics Inc 0.13
DICE Therapeutics Inc 0.12
Seres Therapeutics Inc 0.12
SomaLogic Inc 0.11
Freenome Holdings Inc 0.10
Freenome Holdings Inc 0.10
Hemoshear Therapeutics LLC 0.09
Centessa Pharmaceuticals PLC (ADR) 0.09
Neurogene Inc 0.09
Phathom Pharmaceuticals Inc 0.09
Attralus Inc 0.08
Edgewise Therapeutics Inc 0.08
Neurogene Inc 0.08
Rhythm Pharmaceuticals Inc 0.08
Magnolia Medical Technologies Inc 0.08
Olema Pharmaceuticals Inc 0.07
Flame Biosciences Inc 0.07
DICE Therapeutics Inc 0.07
Twinstrand Biosciences Inc 0.07
Disc Medicine Inc 0.06
Arbor Biotechnologies Inc 0.06
Sonoma Biotherapeutics Inc 0.06
C4 Therapeutics Inc 0.06
4D Molecular Therapeutics Inc 0.06
Asher Biotherapeutics Inc 0.05
Icosavax Inc 0.04
Bigfoot Biomedical Inc 0.04
Lexeo Therapeutics Inc 0.04
Canbridge Pharmaceuticals Inc 0.04
BioAtla Inc 0.03
Essa Pharma Inc 0.03
Ventyx Biosciences Inc 0.02
Canbridge Pharmaceuticals Inc 0.02
SomaLogic Operating Co Inc 0.00
Clementia Pharmaceuticals Inc 0.00
Cash & Equivalents 0.67
Janus Henderson publishes this listing of securities held as of the most recently available disclosure period, which varies depending on the portfolio. Any portion of holdings may be excluded from publication when deemed in the best interest of the portfolio. Securities are reported at market value.
The portfolio data and its presentation here is based on the investment book of record and may differ from the accounting book of record and complete schedules of investments in regulatory filings due to differing accounting and reporting standards.