For Financial Professionals in the US

Global Life Sciences Diversified ADR Managed Account

By understanding the science and business of health care, our experienced team invests in companies addressing unmet medical needs or improving efficiencies

Overview

ABOUT THIS PORTFOLIO

This global health care portfolio seeks consistent returns by investing in companies addressing unmet medical needs or making the health care system more efficient. We balance the portfolio across pharmaceuticals, biotechnology and services/devices sub-sectors in an effort to achieve consistent outperformance of the benchmark and peers.

WHY INVEST IN THIS PORTFOLIO

Finding Growth in Health Care:
The long-term drivers of growth in the health care sector include rapidly accelerating innovation addressing unmet medical needs, powerful global demographic trends and the globalization of health care. Within this environment, the Portfolio seeks to invest in growth companies that are addressing unmet medical needs or making the health care system more efficient and cost effective.

Dedicated Sector Experts:
Our dedicated team of analysts has over a century of combined experience investing in health care companies. In this complex and rapidly growing sector, we believe it is critical to have an experienced team that seeks to understand both the science and the business of the companies in which they invest.

Deep and Disciplined:
We believe the combination of deep, fundamental research and disciplined portfolio construction will lead to consistently strong results relative to both the health care sector and the broader equity market. The Portfolio is balanced across the sub-sectors of health care and diversified across market-cap segments and geographies.

PORTFOLIO MANAGEMENT

Andy Acker, CFA

Portfolio Manager

Industry since 1996. Joined Firm in 1999.

Performance

RETURNS (%) (As of 12/31/2020)
Composite Pure Gross* Composite Net MSCI World Health Care Index (Gross)
 
3M YTD 1YR 3YR 5YR 10YR Since Inception
(01/01/1999)
Composite Pure Gross* 11.31 19.08 19.08 17.21 11.96 18.74 12.90
Composite Net 10.51 15.65 15.65 13.83 8.72 15.32 9.63
MSCI World Health Care Index (Gross) 6.93 14.10 14.10 13.36 10.44 14.08 7.36
RETURNS (%) (As of 02/28/2021)
Composite Pure Gross* Composite Net MSCI World Health Care Index (Gross)
 
3M YTD 1YR 3YR 5YR 10YR Since Inception
(01/01/1999)
Composite Pure Gross* 3.17 -0.95 28.85 15.44 15.72 18.12 12.75
Composite Net 2.42 -1.44 25.16 12.10 12.38 14.71 9.48
MSCI World Health Care Index (Gross) 1.44 -1.64 22.13 12.39 12.16 13.44 7.36

RETURNS-BASED STATISTICS (Composite As of 03/31/2021)

RISK / REWARD
VS. MSCI World Health Care Index (Gross)
3YR 5YR
Information Ratio 0.08 0.37
Alpha -0.40 1.10
Tracking Error 7.06 6.52
Beta 1.09 1.12
R-squared (%) 84.95 84.55
UP/DOWN MARKET CAPTURE (%)
VS. MSCI World Health Care Index (Gross)
3YR 5YR
Up Capture Ratio 107.39 113.90
Down Capture Ratio 108.04 106.10
STANDARD DEVIATION 3YR 5YR
Janus Henderson Global Life Sciences Diversified ADR Managed Account 17.84 16.12
MSCI World Health Care Index (Gross) 15.02 13.29
SHARPE RATIO 3YR 5YR
Janus Henderson Global Life Sciences Diversified ADR Managed Account 0.74 0.83
MSCI World Health Care Index (Gross) 0.84 0.83

Portfolio

Index represents the Index represents the MSCI World Health Care Index (Gross).

Top Holdings (As of 03/31/2021)
% of Rep Account
UnitedHealth Group Inc 3.99
AstraZeneca PLC (ADR) 3.93
AbbVie Inc 3.23
Merck & Co Inc 2.99
Novartis AG (ADR) 2.90
Roche Holding AG (ADR) 2.84
Humana Inc 2.62
Boston Scientific Corp 2.49
Abbott Laboratories 2.45
Vertex Pharmaceuticals Inc 2.31
Total 29.75
View Full Holdings
Portfolio Characteristics (As of 03/31/2021)
  REP ACCOUNT INDEX
Number of Holdings
Equity Issues
89 158
Market Capitalization
Weighted Average
$91.88B $139.91B
Portfolio Turnover Rate
(1-year trailing)
34.75% -
Price/Earnings Ratio
(1-year forward)
22.21 22.96
Price/Book Ratio
(1-year forward)
6.29 6.78
Earnings Growth Rate
(1-year forward)
15.37% 13.01%
Sector Allocation % OF REP ACCOUNT % of Index % OF REP ACCOUNT % of Index (As of 03/31/2021)
Health Care 98.10 100.00
Cash & Equivalents 1.90 -
Regional Allocations % OF REP ACCOUNT % of Index % OF REP ACCOUNT % of Index (As of 03/31/2021)
North America 80.60 70.84
Europe 15.61 20.80
Japan 1.89 6.06
Cash & Equivalents 1.90 -
MARKET CAPITALIZATION RANGE OF EQUITY HOLDINGS % OF REP ACCOUNT % OF INDEX % OF REP ACCOUNT % OF INDEX (As of 03/31/2021)
Over $100B 36.78 49.52
$50B to $100B 16.18 23.18
$10B to $50B 17.83 25.24
$5B to $10B 10.81 1.64
$1B to $5B 13.29 0.15
$500M to $1B 2.02
$250M to $500M 0.77
N/A 0.42 0.27
Developed VS Emerging Markets % OF REP ACCOUNT % of Index % OF REP ACCOUNT % of Index (As of 03/31/2021)
U.S. 80.23 70.58
Non-U.S. Developed 17.87 29.42
Cash & Equivalents 1.90 -

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